Publikációink

Comparative Evaluation of Mutect2, Strelka2, and FreeBayes for Somatic SNV Detection in Synthetic and Clinical Whole-Exome Sequencing Data.

López-Cade I, Gómez-Sanz A, Sanvicente A, Díaz-Tejeiro C, Manzano A, Pérez-Segura P, Győrffy B, Ocaña A, de la Hoya M, García-Barberán V. Biomolecules. 2025 Oct 30;15(11):1532. doi: 10.3390/biom15111532. PMID: 41301450

Targeting the HMGB1-IL32 pathway to alleviate T cell exhaustion in epithelial ovarian cancer.

Murmu A, Győrffy B. Geroscience. 2025 Nov 15. doi: 10.1007/s11357-025-01963-5. Online ahead of print. PMID: 41240232

The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 in Breast Cancer Pathophysiology.

Habenicht L, Hassan N, Espinoza-Sànchez NA, Onyeisi JOS, Győrffy B, Hanker L, Greve B, Götte M. Cells. 2025 Oct 17;14(20):1612. doi: 10.3390/cells14201612. PMID: 41148827

Prolonged survival in a patient with pbrm1 mutated metastatic cholangiocarcinoma receiving tazemetostat.

Pedregal M, Morafraile EC, Garrido A, Doger B, Hernandez T, Morillo D, Győrffy B, Ocaña A, Minguez P, Moreno V. NPJ Precis Oncol. 2025 Oct 24;9(1):331. doi: 10.1038/s41698-025-01113-2. PMID: 41136536

Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy.

Ungvari Z, Fekete JT, Fekete M, Lehoczki A, Gulej R, Sorond F, Liotta E, Prodan CI, Toth P, Kiss C, Ungvari A, Győrffy B. Geroscience. 2025 Oct 16. doi: 10.1007/s11357-025-01915-z. Online ahead of print. PMID: 41102478

Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling.

Zdársky B, Edtmayer S, Witalisz-Siepracka A, Weiss S, Boigenzahn S, Heindl K, Zahma S, Győrffy B, Moriggl R, Stoiber D. Blood Neoplasia. 2025 Aug 4;2(4):100158. doi: 10.1016/j.bneo.2025.100158. eCollection 2025 Nov. PMID: 41090159

Recent advances in treating age-related macular degeneration and diabetic retinopathy: Current therapies and emerging novel approaches.

Antal R, Benyó Z, Nagy ZZ, Kovács I, Fekete JT, Győrffy B, Kovács KA. Geroscience. 2025 Oct 12. doi: 10.1007/s11357-025-01921-1. Online ahead of print. PMID: 41076606

Pathway-level mutational signatures predict breast cancer outcomes and reveal therapeutic targets.

Posta M, Győrffy B. Br J Pharmacol. 2025 Dec;182(23):5734-5747. doi: 10.1111/bph.70215. Epub 2025 Oct 7. PMID: 41057034

Senescence-associated gene signatures predict survival in lung cancer: a multi-cohort analysis.

Ungvári Z, Menyhart O, Ocana A, Fekete M, Lehoczki A, Győrffy B. Geroscience. 2025 Sep 27. doi: 10.1007/s11357-025-01894-1. Online ahead of print. PMID: 41014483

PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding.

Tian L, Jiao X, Wang C, Li D, Ertel A, Achinger-Kawecka J, Addya S, Soccio RE, Chen ER, Győrffy B, Di Sante G, Zhong Z, Alkhafaji H, Entcheva N, Campbell EM, McCue PA, Kossenkov AV, Pancsa R, Tompa P, Clark SJ, Pestell RG. Oncogene. 2025 Sep;44(37):3476-3492. doi: 10.1038/s41388-025-03492-z. Epub 2025 Jul 26. PMID: 40715464

Identification of Deregulated Proteins in Mutated BRCA1/2 Breast and Ovarian Cancers for Vectorized Biologics.

Sanvicente A, Nieto-Jiménez C, Morafraile EC, Díaz-Tejeiro C, Barberán VG, Segura PP, Balázs G, Ocaña A. Cancers (Basel). 2025 Jul 1;17(13):2208. doi: 10.3390/cancers17132208. PMID: 40647506

Multiplicity corrections in life sciences: challenges and consequences.

Menyhárt O, Győrffy B. Int J Epidemiol. 2025 Jun 11;54(4):dyaf098. doi: 10.1093/ije/dyaf098. PMID: 40579911

PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience.

Ungvari Z, Menyhart O, Lehoczki A, Fekete M, Bianchini G, Győrffy B. Geroscience. 2025 Jun 27. doi: 10.1007/s11357-025-01733-3. Online ahead of print. PMID: 40576911

The Prognostic Value of the Hedgehog Signaling Pathway in Ovarian Cancer.

Salman ND, Hanker LC, Győrffy B, Bartha Á, Proppe L, Götte M. Int J Mol Sci. 2025 Jun 19;26(12):5888. doi: 10.3390/ijms26125888. PMID: 40565349

Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian Cancer.

Raab M, Gasimli K, Győrffy B, Peña-Llopis S, Becker S, Sanhaji M, Strebhardt K. Cancers (Basel). 2025 Jun 8;17(12):1910. doi: 10.3390/cancers17121910. PMID: 40563561

Exploring immune activation patterns in HER2-low and HER2-ultralow breast cancer subtypes.

Munkácsy G, Santarpia L, Győrffy B. Oncologist. 2025 Jun 4;30(6):oyaf081. doi: 10.1093/oncolo/oyaf081. PMID: 40549048

CTHRC1 promotes bone metastasis in prostate cancer.

Sawada Y, Kikugawa T, Onishi T, Arai O, Iio H, Miura N, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Sakakibara I, Győrffy B, Kishida T, Okubo Y, Nakamura Y, Sato S, Miyagi Y, Saika T, Imai Y. Int J Cancer. 2025 Dec 1;157(11):2399-2412. doi: 10.1002/ijc.70012. Epub 2025 Jun 21. PMID: 40542593

NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions.

Ungvari Z, Menyhart O, Lehoczki A, Fekete M, Fazekas-Pongor V, Ocana A, Varga P, Győrffy B. Geroscience. 2025 Jun 19. doi: 10.1007/s11357-025-01736-0. Online ahead of print. PMID: 40537696

A gene set enrichment analysis for cancer hallmarks.

Menyhart O, Kothalawala WJ, Győrffy B. J Pharm Anal. 2025 May;15(5):101065. doi: 10.1016/j.jpha.2024.101065. Epub 2024 Aug 3. PMID: 40496069

Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis.

Ungvari Z, Fekete M, Buda A, Lehoczki A, Munkácsy G, Scaffidi P, Bonaldi T, Fekete JT, Bianchini G, Varga P, Ungvari A, Győrffy B. Geroscience. 2025 Jun 10. doi: 10.1007/s11357-025-01719-1. Online ahead of print. PMID: 40490647

Adipocyte/Tumor cell crosstalk via IGF-1/TXNIP axis promotes malignancy and endocrine resistance in breast cancer.

Caruso A, Accattatis FM, Giordano C, Gelsomino L, Del Console P, Fiorita MF, Gyorffy B, Bianchi L, Carleo A, De Salvo R, Simões BM, Clarke RB, Memeo L, Colarossi C, Aiello E, Conforti F, Fuqua SAW, Todaro M, Stassi G, Morelli C, Sisci D, Bonofiglio D, Catalano S, Andò S, Barone I. Cell Commun Signal. 2025 Jun 3;23(1):262. doi: 10.1186/s12964-025-02262-4. PMID: 40462107

Quantum Size Effects on Andreev Transport in Nb/Au/Nb Josephson Junctions: A Combined Ab Initio and Experimental Study.

Yamazaki H, Csire G, Kucska N, Shannon N, Győrffy B, Takagi H, Újfalussy B. Phys Rev Lett. 2025 May 16;134(19):196002. doi: 10.1103/PhysRevLett.134.196002. PMID: 40446256

In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations.

Nieto-Jiménez C, Garcia-Lorenzo E, Diaz-Tejeiro C, Paniagua-Herranz L, Sanvicente A, Doger B, Moreno I, Pedregal M, Bartolomé J, Manzano A, Munkácsy G, Győrffy B, Pérez-Segura P, Calvo E, Moreno V, Ocana A. Sci Rep. 2025 May 22;15(1):17832. doi: 10.1038/s41598-025-02494-x. PMID: 40404793

Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models.

Raab M, Győrffy B, Peña-Llopis S, Fietz D, Kressin M, Kolaric M, Ebert M, Gasimli K, Becker S, Sanhaji M, Strebhardt K. Cancer Commun (Lond). 2025 Aug;45(8):966-970. doi: 10.1002/cac2.70029. Epub 2025 May 20. PMID: 40391786

No detectable impact of short-term treatment delays on lung cancer survival.

Ungvari Z, Fekete M, Buda A, Lehoczki A, Fekete JT, Munkácsy G, Varga P, Ungvari A, Győrffy B. Geroscience. 2025 May 7. doi: 10.1007/s11357-025-01684-9. Online ahead of print. PMID: 40332453

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti-PD1 resistance in skin cutaneous melanoma.

Kovács SA, Kovács T, Lánczky A, Paál Á, Hegedűs ZI, Sayour NV, Szabó L, Kovács A, Bianchini G, Ferdinandy P, Ocana A, Varga ZV, Fekete JT, Győrffy B. Br J Pharmacol. 2025 Aug;182(16):3903-3922. doi: 10.1111/bph.70052. Epub 2025 May 5. PMID: 40324810

Melanoma Proteomics Unveiled: Harmonizing Diverse Data Sets for Biomarker Discovery and Clinical Insights via MEL-PLOT.

Bartha Á, Weltz B, Betancourt LH, Gil J, Pinto de Almeida N, Bianchini G, Szeitz B, Szadai L, Pla I, Kemény LV, Jánosi ÁJ, Hong R, Rajeh A, Nogueira F, Doma V, Woldmar N, Guedes J, Újfaludi Z, Kim Y, Szarvas T, Pahi Z, Pankotai T, Szasz AM, Sanchez A, Baldetorp B, Tímár J, Németh IB, Kárpáti S, Appelqvist R, Domont GB, Pawlowski K, Wieslander E, Malm J, Fenyo D, Horvatovich P, Marko-Varga G, Győrffy B. J Proteome Res. 2025 Jun 6;24(6):3117-3128. doi: 10.1021/acs.jproteome.4c00749. Epub 2025 May 5. PMID: 40322912

Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types.

Ungvari Z, Fekete M, Buda A, Lehoczki A, Fekete JT, Varga P, Ungvari A, Győrffy B. Geroscience. 2025 May 2. doi: 10.1007/s11357-025-01676-9. Online ahead of print. PMID: 40314846

Exercise and survival benefit in cancer patients: evidence from a comprehensive meta-analysis.

Ungvari Z, Fekete M, Varga P, Munkácsy G, Fekete JT, Lehoczki A, Buda A, Kiss C, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):5235-5255. doi: 10.1007/s11357-025-01647-0. Epub 2025 Apr 12. PMID: 40220151

Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.

Ungvari Z, Fekete M, Lehoczki A, Munkácsy G, Fekete JT, Zábó V, Purebl G, Varga P, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):4899-4920. doi: 10.1007/s11357-025-01637-2. Epub 2025 Apr 11. PMID: 40214959

Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies.

Ungvari Z, Fekete M, Varga P, Lehoczki A, Munkácsy G, Fekete JT, Bianchini G, Ocana A, Buda A, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):5123-5140. doi: 10.1007/s11357-025-01646-1. Epub 2025 Apr 10. PMID: 40210826

Treatment delay significantly increases mortality in colorectal cancer: a meta-analysis.

Ungvari Z, Fekete M, Fekete JT, Lehoczki A, Buda A, Munkácsy G, Varga P, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):5337-5353. doi: 10.1007/s11357-025-01648-z. Epub 2025 Apr 8. PMID: 40198462

Prognostic impact of a senescence gene signature in multiple myeloma.

Lehoczki A, Menyhart O, Andrikovics H, Fekete M, Kiss C, Mikala G, Ungvari Z, Győrffy B. Geroscience. 2025 Jun;47(3):5025-5037. doi: 10.1007/s11357-025-01622-9. Epub 2025 Mar 25. PMID: 40133591

Integrating artificial intelligence in drug discovery and early drug development: a transformative approach.

Ocana A, Pandiella A, Privat C, Bravo I, Luengo-Oroz M, Amir E, Gyorffy B. Biomark Res. 2025 Mar 14;13(1):45. doi: 10.1186/s40364-025-00758-2. PMID: 40087789

Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality.

Ungvari Z, Fekete M, Lehoczki A, Munkácsy G, Fekete JT, Zábó V, Purebl G, Varga P, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):4679-4695. doi: 10.1007/s11357-025-01593-x. Epub 2025 Mar 12. PMID: 40072786

Imbalanced sleep increases mortality risk by 14-34%: a meta-analysis.

Ungvari Z, Fekete M, Varga P, Fekete JT, Lehoczki A, Buda A, Szappanos Á, Purebl G, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):4545-4566. doi: 10.1007/s11357-025-01592-y. Epub 2025 Mar 12. PMID: 40072785

Determinants of response and molecular dynamics in HER2+ER+ breast cancers from the NA-PHER2 trial receiving HER2-targeted and endocrine therapies.

Callari M, Dugo M, Barreca M, Győrffy B, Galbardi B, Vigano L, Locatelli A, Dall'Ara C, Ferrarini M, Bisagni G, Colleoni M, Mansutti M, Zamagni C, Del Mastro L, Zambelli S, Frassoldati A, Biasi O, Pusztai L, Valagussa P, Viale G, Gianni L, Bianchini G. Nat Commun. 2025 Mar 4;16(1):2195. doi: 10.1038/s41467-025-57293-9. PMID: 40038334

MetaAnalysisOnline.com: Web-Based Tool for the Rapid Meta-Analysis of Clinical and Epidemiological Studies.

Fekete JT, Győrffy B. J Med Internet Res. 2025 Mar 6;27:e64016. doi: 10.2196/64016. PMID: 39928123

EpigenPlot: An interactive web platform for DNA methylation-based biomarker and drug target discovery in colorectal cancer.

Müller D, Győrffy B. Br J Pharmacol. 2025 Apr;182(7):1452-1465. doi: 10.1111/bph.17455. Epub 2025 Jan 27. PMID: 39871596

The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer's disease: a meta-analysis.

Fekete M, Varga P, Ungvari Z, Fekete JT, Buda A, Szappanos Á, Lehoczki A, Mózes N, Grosso G, Godos J, Menyhart O, Munkácsy G, Tarantini S, Yabluchanskiy A, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):3111-3130. doi: 10.1007/s11357-024-01488-3. Epub 2025 Jan 11. PMID: 39797935

Prognostic impact of glucagon-like peptide-1 receptor (GLP1R) expression on cancer survival and its implications for GLP-1R agonist therapy: an integrative analysis across multiple tumor types.

Ungvari Z, Bartha Á, Ungvari A, Fekete M, Bianchini G, Győrffy B. Geroscience. 2025 Jun;47(3):4413-4427. doi: 10.1007/s11357-024-01494-5. Epub 2025 Jan 8. PMID: 39777709

Impact of adherence to the Mediterranean diet on stroke risk.

Ungvari Z, Fekete M, Varga P, Fekete JT, Buda A, Szappanos Á, Lehoczki A, Mózes N, Grosso G, Menyhart O, Munkácsy G, Tarantini S, Yabluchanskiy A, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):3565-3581. doi: 10.1007/s11357-024-01491-8. Epub 2025 Jan 7. PMID: 39777701

Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes.

Pla I, Szabolcs BL, Péter PN, Ujfaludi Z, Kim Y, Horvatovich P, Sanchez A, Pawlowski K, Wieslander E, Kuras M, Murillo JR, Guedes J, Pál DMP, Ascsillán AA, Betancourt LH, Németh IB, Gil J, de Almeida NP, Szeitz B, Szadai L, Doma V, Woldmar N, Bartha Á, Pahi Z, Pankotai T, Győrffy B, Szasz AM, Domont G, Nogueira F, Kwon HJ, Appelqvist R, Kárpáti S, Fenyö D, Malm J, Marko-Varga G, Kemény LV. Int J Dermatol. 2025 May;64(5):870-881. doi: 10.1111/ijd.17586. Epub 2024 Dec 25. PMID: 39722169

Understanding the Preclinical Efficacy of Antibody-Drug Conjugates.

Díaz-Tejeiro C, López de Sá A, Poyatos-Racionero E, Ballestín P, Bartolomé J, Calvo E, Moreno V, Moris F, Pérez-Segura P, Gyorffy B, Pandiella A, Ocaña A. Int J Mol Sci. 2024 Nov 29;25(23):12875. doi: 10.3390/ijms252312875. PMID: 39684584

High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML).

Bajrami Saipi M, Ruiba A, Schittenhelm MM, Blumenstock G, Győrffy B, Fazio S, Hafner M, Ahrens AL, Aldinger L, Aellig V, Kavelaars FG, Nombela-Arrieta C, Fend F, Valk PJM, Christoph D, Kampa-Schittenhelm KM. Cell Death Dis. 2024 Nov 30;15(11):869. doi: 10.1038/s41419-024-07190-8. PMID: 39616159

REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1A.

Waters E, Pucci P, Rahman R, Yatsyshyna AP, Porter H, Hirst M, Gromnicova R, Kraev I, Mongiardini V, Grimaldi B, Golding J, Fillmore HL, Győrffy B, Gangadharannambiar P, Velanis CN, Heath CJ, Crea F. PLoS One. 2024 Nov 27;19(11):e0312237. doi: 10.1371/journal.pone.0312237. eCollection 2024. PMID: 39602392

Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers.

Olah C, Mairinger F, Wessolly M, Joniau S, Spahn M, Kruithof-de Julio M, Hadaschik B, Soós A, Nyirády P, Győrffy B, Reis H, Szarvas T. Prostate Cancer Prostatic Dis. 2025 Sep;28(3):773-781. doi: 10.1038/s41391-024-00918-9. Epub 2024 Nov 14. PMID: 39543244

Identification of genetic fingerprint of type I interferon therapy in visceral metastases of melanoma.

Vízkeleti L, Papp O, Doma V, Gil J, Markó-Varga G, Kovács SA, Győrffy B, Kárpáti S, Tímár J. Sci Rep. 2024 Nov 3;14(1):26540. doi: 10.1038/s41598-024-77285-x. PMID: 39489756

Development and validation of a gene expression-based Breast Cancer Purity Score.

Barreca M, Dugo M, Galbardi B, Győrffy B; NA-PHER2 consortium; NeoTRIP consortium; Valagussa P, Besozzi D, Viale G, Bianchini G, Gianni L, Callari M. NPJ Precis Oncol. 2024 Oct 24;8(1):242. doi: 10.1038/s41698-024-00730-7. PMID: 39448787

Senescence-related genes as prognostic indicators in breast cancer survival.

Ungvari Z, Ungvari A, Fekete M, Kiss C, Győrffy B. Geroscience. 2025 Jun;47(3):2995-3006. doi: 10.1007/s11357-024-01384-w. Epub 2024 Oct 21. PMID: 39432147

Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk.

Ungvari Z, Fekete M, Varga P, Lehoczki A, Fekete JT, Ungvari A, Győrffy B. Geroscience. 2025 Jun;47(3):3343-3364. doi: 10.1007/s11357-024-01375-x. Epub 2024 Oct 8. PMID: 39379738

The Immune-Related 27-Gene Signature DetermaIO Predicts Response to Neoadjuvant Atezolizumab plus Chemotherapy in Triple-Negative Breast Cancer.

Dugo M, Huang CS, Egle D, Bermejo B, Zamagni C, Seitz RS, Nielsen TJ, Thill M, Antón-Torres A, Russo S, Ciruelos EM, Schweitzer BL, Ross DT, Galbardi B, Greil R, Semiglazov V, Gyorffy B, Colleoni M, Kelly CM, Mariani G, Del Mastro L, Blasi O, Callari M, Pusztai L, Valagussa P, Viale G, Gianni L, Bianchini G. Clin Cancer Res. 2024 Nov 1;30(21):4900-4909. doi: 10.1158/1078-0432.CCR-24-0149. PMID: 39308141

A Peptide Motif Covering Splice Site B in Neuroligin-1 Binds to Aβ and Acts as a Neprilysin Inhibitor.

Dietz LT, Põld K, Györffy BA, Zharkovsky A, Sørensen JB, Pankratova S, Dmytriyeva O. Mol Neurobiol. 2025 Mar;62(3):3244-3257. doi: 10.1007/s12035-024-04475-z. Epub 2024 Sep 11. PMID: 39261388

LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10.

Major E, Lin KH, Lee SC, Káldi K, Győrffy B, Tigyi GJ, Benyó Z. Acta Pharmacol Sin. 2025 Jan;46(1):222-230. doi: 10.1038/s41401-024-01373-x. Epub 2024 Aug 26. PMID: 39187677

Inflammation and Colorectal Cancer: A Meta-Analysis of the Prognostic Significance of the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI).

Menyhart O, Fekete JT, Győrffy B. Int J Mol Sci. 2024 Aug 2;25(15):8441. doi: 10.3390/ijms25158441. PMID: 39126008

Artificial intelligence methods available for cancer research.

Murmu A, Győrffy B. Front Med. 2024 Oct;18(5):778-797. doi: 10.1007/s11684-024-1085-3. Epub 2024 Aug 8. PMID: 39115792

Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants.

Ungvari Z, Fekete M, Fekete JT, Grosso G, Ungvari A, Győrffy B. Geroscience. 2025 Feb;47(1):1105-1121. doi: 10.1007/s11357-024-01296-9. Epub 2024 Aug 1. PMID: 39090501

STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance.

Witalisz-Siepracka A, Denk CM, Zdársky B, Hofmann L, Edtmayer S, Harm T, Weiss S, Heindl K, Hessenberger M, Summer S, Dutta S, Casanova E, Obermair GJ, Győrffy B, Putz EM, Sill H, Stoiber D. Front Immunol. 2024 Jul 5;15:1374068. doi: 10.3389/fimmu.2024.1374068. eCollection 2024. PMID: 39034990

Mitochondrial dysfunction and immune suppression in BRAF V600E-mutated metastatic melanoma.

Pinto de Almeida N, Jánosi ÁJ, Hong R, Rajeh A, Nogueira F, Szadai L, Szeitz B, Pla Parada I, Doma V, Woldmar N, Guedes J, Újfaludi Z, Bartha A, Kim Y, Welinder C, Baldetorp B, Kemény LV, Pahi Z, Wan G, Nguyen N, Pankotai T, Győrffy B, Pawłowski K, Horvatovich P, Szasz AM, Sanchez A, Kuras M, Rodriguez Murillo J, Betancourt L, Domont GB, Semenov YR, Yu KH, Kwon HJ, Németh IB, Fenyő D, Wieslander E, Marko-Varga G, Gil J. Clin Transl Med. 2024 Jul;14(7):e1773. doi: 10.1002/ctm2.1773. PMID: 39032005

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts.

Szadai L, Bartha A, Parada IP, Lakatos AIT, Pál DMP, Lengyel AS, de Almeida NP, Jánosi ÁJ, Nogueira F, Szeitz B, Doma V, Woldmar N, Guedes J, Ujfaludi Z, Pahi ZG, Pankotai T, Kim Y, Győrffy B, Baldetorp B, Welinder C, Szasz AM, Betancourt L, Gil J, Appelqvist R, Kwon HJ, Kárpáti S, Kuras M, Murillo JR, Németh IB, Malm J, Fenyö D, Pawłowski K, Horvatovich P, Wieslander E, Kemény LV, Domont G, Marko-Varga G, Sanchez A. Front Oncol. 2024 Jul 2;14:1428182. doi: 10.3389/fonc.2024.1428182. eCollection 2024. PMID: 39015503

The m⁶A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism.

Park SH, Ju JS, Woo H, Yun HJ, Lee SB, Kim SH, Győrffy B, Kim EJ, Kim H, Han HD, Eyun SI, Lee JH, Park YY. Exp Mol Med. 2024 Jun;56(6):1373-1387. doi: 10.1038/s12276-024-01235-w. Epub 2024 Jun 3. PMID: 38825643

Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies.

Lukácsi S, Munkácsy G, Győrffy B. Integr Cancer Ther. 2024 Jan-Dec;23:15347354241242094. doi: 10.1177/15347354241242094. PMID: 38818970

A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia.

Edtmayer S, Witalisz-Siepracka A, Zdársky B, Heindl K, Weiss S, Eder T, Dutta S, Graichen U, Klee S, Sharif O, Wieser R, Győrffy B, Poli V, Casanova E, Sill H, Grebien F, Stoiber D. Cell Death Dis. 2024 May 28;15(5):369. doi: 10.1038/s41419-024-06749-9. PMID: 38806478

Clinical and Immunologic Characteristics of Colorectal Cancer Tumors Expressing LY6G6D.

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A Functional Survey of the Regulatory Landscape of Estrogen Receptor-Positive Breast Cancer Evolution.

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Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts.

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T-reg transcriptomic signatures identify response to check-point inhibitors.

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Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors.

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Prognostic significance of a signature based on senescence-related genes in colorectal cancer.

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Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights.

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Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.

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Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction.

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Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells.

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Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2.

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Resistance to Combined Anthracycline-Taxane Chemotherapy Is Associated with Altered Metabolism and Inflammation in Breast Carcinomas.

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Evaluation of apoptosis stimulating protein of TP53-1 (ASPP1/PPP1R13B) to predict therapy resistance and overall survival in acute myeloid leukemia (AML).

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Dietary approaches for exploiting metabolic vulnerabilities in cancer.

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miRNAs in the Box: Potential Diagnostic Role for Extracellular Vesicle-Packaged miRNA-27a and miRNA-128 in Breast Cancer.

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Breast cancers with high proliferation and low ER-related signalling have poor prognosis and unique molecular features with implications for therapy.

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